Klotho and cancer

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August undefined, 2024

WebJul 19, 2010 · Klotho, as a new anti-aging gene, can shed into circulation and act as a multi-functional humoral factor that influences multiple biological processes. Recently, published studies suggest that klotho can also serve as a potential tumor suppressor. WebOct 1, 2024 · In various tumor types, Klotho downregulation promotes cell proliferation and reduces cancer cell apoptosis. Soluble Klotho reduces tumor growth in vitro and in vivo in …

Klotho inhibits transforming growth factor-beta1 (TGF-beta1 ... - PubMed

WebOct 19, 2024 · The protein Klotho can significantly delay aging, so it has attracted widespread attention. Abnormal downregulation of Klotho has been detected in several aging-related diseases, such as Alzheimer’s disease, kidney injury, cancer, chronic obstructive pulmonary disease (COPD), vascular disease, muscular dystrophy and … WebJul 5, 2013 · The klotho gene is a classical “aging suppressor” gene. Its roles in the pathology of chronic kidney diseases have been well documented. However, the role of Klotho in tumorigenesis, cancer progression, and prognosis is attracting more and more attention. Recent studies have shown that Klotho participates in the progression of … how much time for second degree murders

Klotho Acts as a Tumor Suppressor in Cancers SpringerLink

WebJul 16, 2024 · Klotho has both anticancer and hormone-like functions. But the research on Klotho and cancer is mainly based on animal experiments and small-scale clinical … WebJul 5, 2011 · We have recently identified klotho as a tumor suppressor in breast cancer. Klotho is expressed in the normal pancreas and both the IGF-I and FGF pathways are … WebOct 5, 2009 · Klotho is a transmembrane protein that can be shed and act as a circulating hormone and is a putative tumor suppressor in breast cancer. A functional variant of KLOTHO (KL-VS) contains two amino ... men\u0027s compression shorts with cup

Klotho rewires cellular metabolism of breast cancer cells …

Association of serum Klotho levels with cancer and …

WebMay 18, 2010 · Background Klotho was originally characterized as an anti-aging gene that predisposed Klotho-deficient mice to a premature aging-like syndrome. Recently, KLOTHO … WebAug 29, 2024 · However, klotho possesses multiple pleiotropic activities, including inhibition of major signaling pathways, reducing oxidative stress and suppressing inflammation. These activities are tightly... how much time for rtgs transferWebJun 6, 2024 · Klotho can suppress cancer by inhibiting IGF-1 signaling, which is known to be upregulated in cancer cells and promotes cancer growth and metastasis [ 6, 14 ]. In addition, klotho has been found to inhibit tumor growth by acting on the FGF, phosphatidylinositol 3-kinase/Akt, WNT, transforming growth factor β, and unfolded protein response pathways. men\\u0027s compression shorts size 66

"WebNov 1, 2014 · It has been reported that KL, as a tumor suppressor, downregulates insulin growth factor (IGF) signaling pathway that is involved in tumorigenesis and progression of many human cancers, including... " - Klotho and cancer

Klotho and cancer

WebCancer stem cells (CSC) play a crucial role in the process of tumor initiation, progression, recurrence, and drug resistance. ... Gunes et al. used CRISPR to up-regulate Klotho gene in colon cancer cell Caco-2, and found that cell proliferation was inhibited and tumorigenic recovery was achieved, ... WebKlotho (KL) is a putative tumor suppressor gene in breast and pancreatic cancers located at chromosome 13q12. A functional sequence variant of Klotho (KL-VS) was previously …

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WebMar 12, 2024 · α-Klotho is a geroprotective protein that can attenuate or alleviate deleterious changes with ageing and disease. Declines in α-Klotho play a role in the pathophysiology … WebApr 15, 2024 · The Klotho gene (also known as α-Klotho) is located on chromosome 13q12 and it was first identified as an anti-aging factor 33. It is expressed in the kidney and even less in the pancreatic ...

WebThe effects of beta-Klotho and FGF-15 on the ileal apical sodium bile transporter (ASBT) are unknown. beta-Klotho siRNA treatment of the mouse colon cancer cell line, CT-26, and the human intrahepatic biliary epithelial cells (HIBEC) resulted in upregulation of endogenous ASBT expression that was associated with reduced expression of the ... WebNew Publication by Junfeng Ma, et al. Initially discovered by Makuto Kuro-o in 1997, Klotho is a putative aging-suppressor gene when overexpressed and accelerates aging when deleted in mice. Previously, we showed that α-Klotho regulates retinal pigment epithelium (RPE) functions and protects against oxidative stress. However, the mechanisms by …

WebNov 1, 2024 · Klotho effects on cancer cells in vitro and in vivo. As stated, Klotho inhibits many pathways involved in carcinogenesis, including IGF1R (with downstream PI3K, Akt, and mTOR signaling), Wnt/β-catenin signaling, FGF2 signaling (generally affecting ERK1/2 signaling), and TGFβ1 and downstream Smad2/3 signaling. ... WebJan 1, 2016 · Studies show that klotho is universally silenced in a wide array of malignancies, including breast, pancreatic, ovarian, lung, colorectal, and melanoma, and that klotho's expression can serve as an invaluable prognostic marker.

WebFeb 7, 2024 · Background: Calcific aortic valve disease (CAVD) is a chronic inflammatory disease. Soluble extracellular matrix (ECM) proteins can act as damage-associated molecular patterns and may induce valvular inflammation. Matrilin-2 is an ECM protein and has been found to elevate the pro-osteogenic activity in human aortic valve interstitial …

WebDec 15, 2024 · Klotho is an anti-aging transmembrane protein, which can be shed and can function as a hormone. Accumulating data indicate that klotho is a tumor suppressor in a … how much time for rtgsWebKlotho functions as a tumor suppressor mainly by regulating insulin/IGF-1, p53/p21, and Wnt signaling pathways. Thus, Klotho involves in multiple biological processes, especially in anti-aging and inhibition of cancer, and it may be a potential key link between cancer and aging. men\u0027s compression shirts 3xlWebMay 12, 2024 · Klotho is epigenetically silenced in cancer and treatment with either soluble klotho or overexpression reduces growth of cancer cells in vitro and in vivo [10, 17]. men\u0027s compression liner swim trunksWebDec 15, 2024 · Klotho is an anti-aging transmembrane protein, which can be shed and can function as a hormone. Accumulating data indicate that klotho is a tumor suppressor in a wide array of malignancies, and ... men\u0027s compression shorts size 66WebThese findings further support the role of Klotho as an anti-tumor gene in human thyroid cancer. Klotho is known as an anti-tumor gene that acts as a circulating hormone to inhibit cancer cell proliferation and migration by modulating tumor-related signal transduction. 9 Our results further reveal that Klotho has an anti-tumor role in RET ... men\u0027s compression shorts for hip painWebIntroduction. Prostate cancer (PCa) is considered as the most diagnosed cancer for men in 2024 worldwide, with 191,930 new cases, accounting for almost 21.5% newly diagnosed … men\u0027s compression shorts nikeWebNov 1, 2024 · Taken together, it is well-established that Klotho deficiency is both associated with renal fibrotic disease, as well as induces and exacerbates the development of renal … men\u0027s compression shorts for running