WebMethods Tissue microarray sections of formalin-fixed, paraffin-embedded tissues from clinically verified 11 BAC, 11 CAC, 18 invasive urothelial carcinomas (UCs), 22 normal urothelium samples, 25 CC and 15 IM were stained for keratin 7, 5/6, 5/14 and 20, ß-catenin, e-cadherin, cadherin 17, cdx2, uroplakin II and III, CD10, androgen receptor … WebJun 1, 2024 · GATA3 expression is down-regulated in UUTUC, compared with normal urothelium. • Only 51.5% of UUTUCs are immunoreactive for GATA3. • Loss of GATA3 …
Evaluation of Contemporary Prostate and Urothelial ... - Oxford …
WebGATA3 is a transcription factor important in the differentiation of breast epithelia, urothelia, and subsets of T-lymphocytes. It has been suggested useful in the evaluation of mammary or urothelial origin or metastatic carcinomas, but its distribution in normal and neoplastic tissues is incompletely mapped. WebApr 12, 2024 · c Contrast between GATA3-staining normal urothelium and GATA3-negative SCC. d Focal CK7 immunostaining of SCC with obvious positivity of adjacent normal urothelium. Full size image. Two months following discharge, he developed recurrence of malaise and bone pains and was admitted at another hospital. inc and catholic
GATA3 expression loss is linked to stage progression but …
WebGATA3 emerged as good prognostic marker; while ERα-positivity was associated to higher grade tumours. ERα and ERβ were inversely correlated with GATA3 expression. ... The two ERs (ERα and ERβ) are expressed in the normal urothelium of both sexes . Analysis of the TCGA urothelial cancer data set (n=406) showed that ERα and ERβ mRNA ... WebOct 1, 2016 · GATA-3 was present in the full thickness of the urothelium, whereas p40 was most highly expressed in the basal and intermediate cells of the urothelium . Download : … WebThe study by Parker and colleagues 416 demonstrated a sensitivity of 57% for uroplakin III (UROIII) and a nearly perfect specificity. Unlike uroplakin, thrombomodulin (TM) is a highly sensitive but unspecific marker of urothelial differentiation ( Fig. 8.19 ). Thrombomodulin is an endothelial cell surface glycoprotein that forms a 1:1 complex ... in between buttocks rash